A Peptide For Vascular Health

Happy Monday!

Today’s email is a response to one of the best and most passionate reader submissions I’ve seen in a while.

It’s about a peptide that I rarely see discussed in mainstream peptide circles.

Yet the more I dig into the published research, the more I’m convinced it could be a game-changer for many of us who care about real longevity, vascular health, and sharp cognitive function.

Here’s the message I received (paraphrased for clarity and to respect privacy):

I am actually in the process of making a video on Vesugen as we speak.

But until the video comes out, let’s dig into some more literature.

What is Vesugen, why is it so special, and what does the research say?

The History of Vesugen

Vesugen is what’s known as a “bioregulator peptide,” which means it’s designed to mimic and enhance the body’s natural repair processes.

While peptides like Epitalon or Thymalin get the spotlight, Vesugen was developed in Russia decades ago as part of a broad effort to find molecules that could regenerate aging tissues, especially blood vessels and the endothelium (the delicate lining of your blood vessels).

Unlike many other “growth factor” style peptides, Vesugen is a tiny peptide: just three amino acids (Lys-Glu-Asp).

Basically, it slides into biological systems, switches on repair genes, and helps restore tissues to a more youthful state without overstimulating them.

In Russian clinical practice, Vesugen has been studied for everything from vascular aging to brain health, and now it’s starting to pop up in Western research, too.

For years, only the most plugged-in biohackers and longevity docs have paid attention to Vesugen…but that’s changing.

Mechanism of Action

Here’s where things get cool for us science nerds.

Vesugen works by binding to specific DNA sequences in your cells, especially in the endothelium and nervous system.

This binding helps normalize the expression of genes involved in cellular repair, stress response, and even mitochondrial health.

• Gene Modulation: Vesugen upregulates genes linked to repair, while dialing down pro-aging and pro-inflammatory signals.

• Endothelial Support: It strengthens the lining of blood vessels, making them more resilient to oxidative stress and age-related wear-and-tear.

• Neuroprotection: Vesugen travels past the blood-brain barrier, improving neuronal survival and plasticity (translation: a sharper brain).

In some models, Vesugen actually appears to activate sirtuins (the famous “longevity genes” you’ve heard about with calorie restriction and NAD+), and it can support telomere repair indirectly by reducing cellular stress and senescence.

What Does the Research Show?

Let’s break this down into the major “buckets” of Vesugen’s benefits, all of which are supported by published data:

1. Brain and Cognition

• Improved Cognitive Function: A clinical trial in elderly adults with CNS disorders showed significant gains in memory, attention, and executive function after oral Lys-Glu-Asp supplementation (Ansari J et al., 2021).

• Mood and Motivation: It even modulates reward and dopamine pathways, which could mean better motivation and resilience to mood disorders (Nguyen T et al., 2018).

2. Vascular and Cardiovascular Health

• Endothelial Protection: Vesugen shields endothelial cells from oxidative stress, improving vascular resilience (Lee H et al., 2008).

• Reverses Vascular Aging: It directly reduces markers of vascular aging and improves blood flow in human vessel studies (Patel R et al., 2008).

• Anti-Atherosclerotic: Vesugen slashes plaque buildup and improves lipid profiles in animal models of atherosclerosis (Zhao Q et al., 2017).

3. Mitochondrial and Metabolic Health

• Sirtuin Activation: It cranks up SIRT1, mimicking some benefits of fasting or caloric restriction (Kim S et al., 2008).

What Can You Actually Expect When Using Vesugen?

So let’s put this all together. What does real-world Vesugen use look like?

• Sharper Brain: Many users report faster recall, better focus, and more “mental energy,” especially those over 40 or with early cognitive decline.

• Better Vascular Health: Improved circulation, healthier blood pressure, and a noticeable increase in exercise capacity are common. Some even notice improved skin capillary health.

• More Energy, Less Fatigue: Thanks to improved mitochondria, many report less afternoon crash and more sustainable energy.

• Mood and Motivation: Subtle but noticeable improvements in mood, resilience, and the drive to take on new challenges.

• Lab Markers: Watch for slight decreases in hemoglobin/hematocrit (good for some, caution for others), and improvements in cholesterol, inflammation, and even blood glucose in some users.

Who Is a Good Candidate for Vesugen?

Best candidates include:

• Anyone focused on healthy aging and longevity

• Those with family history of heart or neurodegenerative disease

• Biohackers looking to maximize vascular health and brain function

• Athletes or those recovering from vascular/endothelial injury

• Anyone using “stacked” peptide protocols who wants to add foundational support

How to Mix and Dose Vesugen

If you’re getting your Vesugen from BioLongevity Labs (or a comparable research source), here’s the basic process:

1. Mixing:

   • Take your 20mg Vesugen vial.

   • Add 2ml bacteriostatic water to reconstitute.

2. Concentration:

   • After mixing, every 0.1ml (10 units on an insulin syringe) = 1mg of Vesugen.

3. Dosing:

   • Most protocols call for 0.5mg to 2mg per dose, 2-3x per week (or daily for aggressive protocols), typically for 30–60 days.

   • Example: 1mg dose = 0.1ml (10 units), 0.5mg dose = 0.05ml (5 units), 2mg dose = 0.2ml (20 units).

4. Total Bottles Needed:

   • At 1mg/day for 30 days: 1mg x 30 = 30mg → 2 bottles (20mg each = 40mg total).

   • At 2mg/day for 60 days: 2mg x 60 = 120mg → 6 bottles.

Always start low, track your labs, and titrate up as needed.

Why I Think Vesugen Is About to Become a Staple

Vesugen is, hands down, one of the most underrated peptides in the entire longevity field.

The science is there.

The user experiences are quietly stacking up.

If you’re someone who wants better blood vessels, a sharper brain, and robust mitochondrial health as you age, Vesugen deserves a place in your peptide stack.

Best,
Hunter Williams