Can You Stack Tirzepatide and Retatrutide?

Every week, I get questions like this:

“Hunter, Retatrutide is great, but it’s not suppressing my appetite enough. Should I add Tirzepatide? And if so, how do I stack them?”

It’s a fantastic question because appetite suppression is key when using GLP-1 agonists for fat loss, and sometimes, one peptide isn’t enough to get the job done.

So, if you’re in this situation, here’s exactly what I recommend (IF and only IF you are not getting enough appetite suppression from retatrutide alone):

✅ Stack Retatrutide and Tirzepatide together at a 1:1 ratio.

✅ Split the total weekly dose in half, evenly dividing it between both peptides.

✅ For example, if your weekly dose is 2mg, use 1mg of Retatrutide and 1mg of Tirzepatide.

Breaking it down further:

✅ Take 3 injections per week, with each injection containing 0.33mg of Retatrutide and 0.33mg of Tirzepatide.

This dosing strategy provides more stable blood levels, enhances appetite suppression, and minimizes potential side effects.

Now, I know what you’re thinking:

“Isn’t that a bit much?”

Let me explain.

Retatrutide covers multiple pathways (GLP-1, GIP, and glucagon), while Tirzepatide adds extra firepower to the GLP-1 and GIP pathways.

Together, they deliver a synergistic punch to appetite and metabolic control.

The best part? You’ll likely find your cravings drop significantly, and you’ll have an easier time sticking to your fat-loss plan without the nausea or unintended side effects.

BUT… as always, before you dive in, ask yourself:

Are you nailing the basics?

✅ Is your diet dialed in?

✅ Are you training with intensity?

✅ Are you getting enough protein and quality sleep?

If the fundamentals are solid, then stacking Retatrutide and Tirzepatide can take you to the next level.

Give it a try, and let me know how it works for you.

Best,

Hunter Williams

P.S. Tomorrow at 6 PM EST, Jay and I are doing a free live masterclass on all things related to peptide reconstitution. If you want to attend, RSVP using this link.