December 2025 Q&A

Happy Friday!

The December 2025 Q&A is finally live.

As always, if you have a question you want me to answer in my Q&A videos, submit it to my question box.

I get comments, DMs, emails, etc., but the question box organizes everything so I can see the patterns and make content that’s actually useful.

And if you’re inside The Axion Collective, you already know we do live Q&As every Thursday at 8:00 PM Eastern.

Let’s pull some of the most relevant questions from this episode and answer them in today’s email.

5-Amino-1MQ oral vs injectable dosing

For injectable 5-Amino-1MQ, my personal sweet spot is 1 mg/day. You can run it subq or IM if you want it to hit faster. In my experience, IM has a more rapid onset, but subq is still excellent.

Oral dosing is not the same experience pound-for-pound. The oral range where people report noticeable benefits is typically 100–150 mg, but the injectable version at 1 mg is simply more consistent and more “obviously effective” for most people.

Could someone go higher on injectable? Sure. I’ve heard of people pushing 5–10 mg/day. If you love that, more power to you. For me, once I get past 2 mg, it starts feeling too strong. Too much energy, too sped up, not enjoyable. That doesn’t mean it’s wrong. It means it’s dose-dependent and individual.

My starting point for most people is 500 mcg to 1 mg/day, and you can titrate from there.

Flying with peptides

When I fly, I put everything in an insulin cooler with ice packs, and I put it in my checked bag. Yes, checked bags are annoying. Yes, it adds friction. But it also reduces scrutiny and lowers the odds of any weird interaction.

I’ve heard plenty of people say they put peptides in a carry-on and just call it medication if asked, and many have no problems.

Typically, I’ll travel with 3–5 pens depending on what I’m using at the time.

I’m usually at a hotel within 24 hours, so I can get everything into a fridge quickly. That simple approach has been the smoothest for me.

Essential Amino Acids on a GLP-1

I take EAAs every day, and I think they’re beneficial whether you’re on a GLP-1 or not.

If anything, they’re more important when you’re on a GLP-1 because appetite suppression can quietly reduce total protein intake and overall amino acid availability.

I personally use Unmatched Supplements because they’re the best-tasting. They’ve got different versions, including a longevity EAA formulation and an intra-workout option, which fits exactly how I already train and supplement.

There are injectable amino blends out there.

And yes, injectable tends to be more “efficacious” in terms of acute effect.

I like injectable amino blends pre-workout when someone wants to feel it fast and strong. But if you’re looking for the “most sustainable forever habit,” EAAs orally are still one of the best ROI moves you can make, especially in a GLP-1 context.

B7-33

This one is making the rounds fast.

B7-33 is being discussed as an anti-fibrotic peptide and something that may also lower blood pressure. Do we have clean human data yet? Not that I’ve seen.

But the reason it’s showing up everywhere is that the mechanistic story is interesting, and the early research signals are exciting enough that people are experimenting.

As far as dosing goes, I don’t have a personal protocol yet, but I’ve heard of people using 1 mg per day, which matches what I see most often in discussions.

Some people are also doing 300 mcg every 6 hours. Personally, if you want to be conservative, you could start at 300 mcg/day and work up to 1 mg/day if you tolerate it well.

Testosterone Before Date Night

I loved this question because it’s the kind of thing everyone wonders, but nobody asks their doctor.

Can you dose testosterone before date night? Yes. But whether you feel anything depends on the ester and delivery method.

If you inject something slow like cypionate right before a date, you might not notice much in the moment. Some people claim they do, but it’s not the most predictable lever.

If you want more immediate “pickup,” you’re looking at things like:

I think there’s a legitimate use case for having testosterone cream on hand for date night, training, or a situation where you want a small bump. The mistake is thinking all testosterone is the same tool. The method is the tool.

Avoiding Injection Nodules

Rotating sites is still step one, but if you’re already rotating and you’re still building tender spots, you need to think about tissue quality and fascia.

One of my simplest tricks is lacrosse ball work. Yes, even on the belly.

A foam roller is hard to use on certain areas, but a lacrosse ball (or a slightly softer spiky ball) lets you apply controlled pressure and work through adhesions. It’s tender, but it works.

Coming off GLP-1s

If your main issue coming off GLP-1s is appetite rebound, one of my favorite off-cycle tools is orforglipron (the new oral GLP-1 small molecule).

For me, I get very strong appetite suppression in the 12–18 mg daily range.

Do I think it burns as much fat as retatrutide or tirzepatide? No. But appetite suppression can be just as effective or even better for some people.

Another option is cagrilintide (different pathway), but a lot of people don’t tolerate it well.

So if you’re coming off a GLP-1 and you want appetite control without the same “feel,” that’s a direction worth exploring.

More in the Video

If you want the deeper answers, the Q&A goes into a bunch of other topics that didn’t make it into this write-up, including:

So if any of those jumped out at you, go watch the full episode.

Final Thoughts

I always tell you guys this, and I mean it.

Without you, I don’t exist.

Your questions shape my content. They tell me what’s confusing, what’s trending, what needs a deeper dive, and what I need to explain better.

If you have a question, submit it through the question box. That’s the best way to make sure I actually see it.

And if you want to ask live, join us in The Axion Collective on Thursdays at 8 PM Eastern.

Have a fantastic weekend!

Best,

Hunter Williams