Does Retatrutide Build Muscle?

Happy Friday!

My bold prediction for 2025 is that Retatrutide will be the best-selling peptide in the research market.

So, in continued dedication to providing you with top-notch education, I will take the time to answer a very important question I recently received in my questions box (remember, you can always submit questions or suggestions for videos here). 

Here’s the question:

Excellent question, and it requires a complex answer.

Let’s break this down:

1. Retatrutide’s Anabolic Properties

Retatrutide is a triple agonist that influences GLP-1, GIP, and glucagon receptors.

It boosts fat loss, improves insulin sensitivity, and enhances muscle protein synthesis—hence its anabolic potential.

This means that your body can retain or even build muscle even in a caloric deficit, provided your training and recovery are optimized.

2. Why You’re Not Seeing Weight Loss (Yet)

It’s common for the scale not to budge initially when starting retatrutide. Here’s why:

• Water retention: Retatrutide (like most peptides) can cause temporary fluid retention, masking weight loss on the scale.

• Muscle gain: As your body improves nutrient partitioning, which is very common on retatrutide, you are likely building muscle, which offsets fat loss in terms of the scale weight.

• Metabolic adaptation: Your body is recalibrating to a healthier, higher metabolic state, which takes time (at least 8-12 weeks).

3. Eating in a Deficit vs. Maintenance/Surplus

To answer the question…

Yes, you can absolutely get leaner while eating at a deficit on retatrutide. The key is patience.

Your body is becoming more efficient at burning fat while preserving muscle—exactly what you want during fat loss.

That said, if your goal is to build muscle, eating at maintenance or a slight surplus would maximize the anabolic effects while minimizing fat gain.

My Recommendation:

• Stay consistent: Keep your caloric deficit, but ensure you get enough protein (at least 1g per pound of lean body mass OR your goal weight).

• Incorporate GH peptides: To enhance muscle preservation and fat loss further, consider adding ipamorelin, tesamorelin, or HGH.

• Perform fasted cardio: This can accelerate fat loss, particularly when combined with retatrutide’s metabolic benefits.

• Use SLU-PP-332: This mitochondrial support molecule optimizes nutrient partitioning and amplifies retatrutide’s effects.

• Optimize hormones: Ensure hormonal balance through testosterone, estradiol/progesterone (for women), and consider desiccated thyroid to support metabolic health during a fat loss phase.

• Track progress: Instead of relying solely on the scale as an indicator, monitor fat loss using body measurements, progress photos, or a BodPod.

• Train smart: Prioritize resistance training to positive muscle failure (PMF) to stimulate muscle growth and maximize the anabolic potential of retatrutide.

If you stick to the plan, your body will respond.

After witnessing thousands of folks report back to me, I don’t know of a more failsafe method of torching fat.

And, as always…

Keep the questions coming!

Best,

Hunter

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