How to Fix Injection Lumps

Happy Thursday!

A reader recently wrote in:

If you have been injecting peptides long enough, you have probably experienced this same issue.

Tender knots.

Lumps under the skin.

Sites that stay sore for days or even weeks.

It is frustrating, especially when you are doing everything right by rotating injection sites.

So today I want to address this head-on, with what I personally do.

I walked through this exact scenario this week because the first thing I did when I got home from traveling from my honeymoon was give myself a glutathione injection.

Glutathione and Recovery

Travel wears us all down.

Jet lag, inflammation, disrupted sleep, and stress all stack up.

Glutathione is one of my most reliable tools for recovery, detoxification, and getting my body back on track after long flights.

The downside is that it stings intensely and is well known for leaving painful lumps under the skin.

Over the years, I developed a small routine that keeps me from dealing with soreness or scar tissue that lingers.

The inconvenient truth is that injection site reactions are part of the deal when you use peptides, but you can manage them if you know what to do.

Here is my step-by-step approach, starting with something that has become non-negotiable for me.

Step One: BioRegenix Cream

The first thing I do after an injection is apply BioRegenix cream from BioLongevity Labs.

Yes, I am promoting one of our products, but I also use this cream every single day on my injection sites because it works.

BioRegenix is powered by peptide bioregulator technology.

It stimulates cellular activity at the molecular level and accelerates the repair of soft tissue damage resulting from repeated injections.

It calms inflammation, reduces tenderness, and prevents the formation of scar tissue.

Over time, this makes a massive difference in keeping tissue soft and healthy.

When people ask me why my injection sites look fine after years of daily self-experimentation, BioRegenix is the reason.

Without it, my belly, delts, and glutes would be covered in scar tissue.

Step Two: Massage Gun Therapy

The second thing I do, especially with compounds like GHK-Cu that often leave lumps, is use a massage gun.

I hit the injection site for two to three minutes right after injecting.

When you inject peptides, you are forcing fluid into tissue that is not used to holding that volume.

Sometimes it pools, and sometimes it irritates nerve endings.

By breaking it up mechanically with a massage gun, you disperse the liquid and increase blood flow in the area.

That means faster absorption, less soreness, and fewer hard nodules that stay around for weeks.

If you have ever had a painful lump in your delt that made training uncomfortable, you will understand why this habit is worth the effort.

Step Three: Foam Rolling

Foam rolling is essential for me, not only for muscle recovery but also for keeping injection sites healthy.

I roll for five to ten minutes every day before my workouts.

Over time, repeated injections can create adhesions in the fascia.

This is a technical way of saying the tissue loses its natural glide and becomes more prone to knots and irritation.

Foam rolling keeps the tissue pliable, improves circulation, and helps your body process inflammation.

This practice protects long-term tissue health. If you plan to use peptides for years, foam rolling is as important for protecting your body as optimizing your hormones.

Step Four: Site Rotation Strategy

The last step is being very strict about site rotation.

Too many people cut corners here, and the result is scar tissue that builds up quickly.

For subcutaneous injections, I make sure to use the entire belly.

Not just one or two spots, but all the way across.

I think of it like a grid system and keep track mentally of which zones I used most recently.

For intramuscular injections, I rotate between each delt and each glute.

Every shot has a different location. That gives tissue plenty of time to recover before I use it again.

Most people who struggle with nodules are not actually rotating as much as they think.

This one habit alone can change everything.

The Reality of Injection Lumps

If you are serious about using peptides, tissue buildup and occasional lumps are part of the process.

You cannot avoid it entirely.

But you can manage it.

With BioRegenix cream, massage gun work, foam rolling, and disciplined site rotation, the problem becomes minimal.

I know that when I inject glutathione, L-carnitine, or GHK-Cu, I am covered.

My tissue stays healthy, my recovery is faster, and I do not dread the process.

That is what I want for all of you.

Is it perfect?

No, but it’s a system that allows you to inject safely and effectively for years without your glutes or belly turning into scar tissue.

If you are dealing with painful nodules, do not give up.

Adjust your strategy, take care of your tissue, and keep moving forward!

Best,

Hunter Williams