Happy Monday!
I played football for 17 years, and as a linebacker, that meant nearly two decades of hitting people with my hands.
To this day, my wrists sometimes bother me after a heavy upper-body training day.
Thankfully, we have peptides to help with things like this.
A couple of years back, after a particularly hard day, both wrists were pretty sore.
I had some injectable Cartalax on hand, which is the injectable cartilage bioregulator.
At the time, I had never come across any dosing information on the injectable versions of these bioregulators.
So I did what I always do, and experimented on myself first.
I pulled 1mg, injected it into the wrist that hurt worse, and left the other one completely alone. Two wrists, one variable. Not a bad little n-of-1.
Then I went to walk my dogs.
Thirty minutes later, I stopped in the middle of the sidewalk because I realized the injected wrist no longer hurt. The other one still did.
That was my introduction to injectable bioregulators, and I've been digging into them ever since.
I recently recorded a full session on injectable bioregulators with Nathalie Niddam.
Nathalie is hosting the Bioregulator and Peptides Summit over at DrTalks, and she asked me to come on and focus specifically on the injectables.
The conversation is live right now.
Head over to that link to view the entire masterclass. Today, I’ll give you a summary of what we covered.
Bioregulators
When people hear the word, they think of the oral capsules.
Those are great. I take them. More published literature backs them than the injectables, by a wide margin.
But I think of the orals as background players. They quietly build an environment in the body that responds better to everything else you're doing. Slow, cumulative, and foundational.
The injectables are a different animal. They're faster, and in my experience they shine in acute situations where the orals just aren't going to get you there.
What we Covered
Why Cartalax works on collagen and elastin everywhere in the body, not just joints
The two-tier dosing framework I use, 100 to 300mcg for general maintenance and 1 to 2mg for acute injury
Why cycling matters and why you shouldn't be hitting these year-round
Vesugen for endothelial function, and why I get a pre-workout-style effect from 300mcg
Stacking logic, including Prostamax with Libidon, and Vilon with Thymalin
Bronchogen and Chonluten for lung issues, and what happened with my father-in-law after a seven-day COPD hospitalization
Why the safety profile is what it is, plus two genuinely terrifying dosing-error stories
Transdermal delivery, which I think is where a lot of this goes next
The Future
Almost everything I shared is personal and coaching experience. I said that on the recording, and I'll say it again here.
Published human literature on injectables is thin compared to the orals.
Most of it is Russian, most of it is decades old, and a lot of it is hard to access.
What I can tell you is that these compounds' mechanisms make sense. BPC-157 and TB-500 suppress inflammation, drive angiogenesis, and pull cells to the injury site. All good things. But none of them seem to affect gene expression the way the bioregulators do.
That's a genuinely different lever, and it's why the effects seem to stick around long after you stop injecting.
Final Thoughts
I feel spoiled by Cartalax at this point.
If I have a soft tissue injury, I inject it a few times, and within days it's gone.
Is that going to be everyone's experience? No. If you have advanced degenerative disease, I'm not going to tell you a 2mg injection is going to fix it.
But if you've been running the standard healing peptides and hitting a ceiling, this is the category I'd look at next.
Go watch the session. Nathalie asks great questions, and we covered a lot of ground in a short window.
Best,
Hunter Williams