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I Stack This With NAD+ Injections
The final piece of the NAD+ puzzle?
Happy Wednesday!
Today I want to talk about a combination that’s had a huge impact on my mitochondrial health, energy, and overall sense of drive: injecting NAD⁺ alongside 5-amino-1MQ, and the little-known supplement that has become a personal favorite of mine.
It’s called NAD Regen.
For the last year, I’ve been experimenting with injecting 50–100 mg of NAD⁺, two to three times a week, and stacking it with 1mg per day of injectable 5-amino-1MQ.
The synergy between these two has been nothing short of remarkable:
NAD⁺ is the fuel for your cellular engines. It boosts sirtuins, DNA repair, and mitochondrial output.
5-amino-1MQ acts as an NAD⁺ preservation molecule, inhibiting the enzyme NNMT that chews up NAD⁺ and wastes your precious cellular currency.
Together, I felt longer-lasting energy, faster workout recovery, and a sharper, more focused mind. But as anyone in the peptide world knows, there’s always another level…
Intro
Initially, I thought my NAD optimization stack was already maxed out.
But a good friend (fellow peptide fanatic and influencer) messaged me: “Have you tried NAD Regen?”
At first, I brushed it off as another “NAD booster” on the market, right?
I’ve heard that one before!
But when I dug into the ingredient panel, I actually thought there might be something to it.
NAD Regen was built to synergize with NAD⁺ therapy, and every component had a place in the NAD/mitochondrial puzzle.
So, I added NAD Regen to my routine and started popping two capsules alongside my NAD⁺ injections.
Within weeks, the difference was noticeable.
The benefits of NAD⁺ lasted longer.
My energy, mental clarity, and post-workout recovery improved massively.
Why NAD Regen is the Perfect Companion to NAD⁺ (and 5-amino-1MQ)
Here’s what makes NAD Regen such a game-changer:
Injectable NAD⁺ gives you a spike, but on its own, those levels can drop quickly.
5-amino-1MQ slows NAD⁺ breakdown, but it doesn’t provide extra building blocks or activate longevity pathways.
NAD Regen supplies:
Substrates for NAD⁺ recycling (niacinamide/copper)
Sirtuin activation (resveratrol)
Gut absorption support (AstraGin®)
Detox and redox balance (wasabi extract)
Autophagy and cellular cleanup (spermidine)
Clean energy (theacrine)
Stacking all three is like switching from regular gasoline to rocket fuel.
Instead of a brief, fleeting peak, you create a sustained, multi-layered support system for cellular energy, repair, and resilience.
The Science
Let’s break down the clinical magic behind each component in NAD Regen, and why it matters:
NAD3® Complex (Wasabi Extract, Theacrine, Cuprous Niacin)
Niacinamide is recycled in the salvage pathway, supporting ongoing NAD⁺ synthesis after your injection boost wears off.
Copper is critical for cytochrome c oxidase. If your mitochondria are working overtime, copper keeps the wheels spinning.
Theacrine offers a smooth, non-habituating energy lift (think: focus without the caffeine crash).
Wasabi extract provides isothiocyanates, ramping up your body’s internal detox system and mopping up oxidative stress from fast-paced metabolism.
Resveratrol
Activates SIRT1, a longevity enzyme that’s NAD⁺-dependent. With plenty of NAD⁺ on board, resveratrol pushes mitochondrial biogenesis, DNA repair, and healthy aging.
AstraGin® (Astragalus & Panax notoginseng)
Proven to increase gut absorption of nutrients, including amino acids and vitamins. When you’re flooding your cells with NAD⁺, you want all the support nutrients to reach peak levels too.
Spermidine
A natural autophagy inducer. Think of it as your cellular “clean-up crew,” removing damaged mitochondria and protein junk that build up when you run your engines hot.
The Clinical Efficacy of NAD Regen
On its own, NAD⁺ is like a massive bank deposit, but without NAD Regen, you might spend it all too fast.
Here’s what the clinical evidence tells us:
NAD3® gives you a recycling mechanism, not just a single spike.
Resveratrol and theacrine help your cells use that NAD⁺ for actual repair and anti-aging, rather than just burning it off.
AstraGin® ensures you’re absorbing every last drop of supportive nutrients you ingest, maximizing oral bioavailability.
Wasabi and spermidine keep the “system clean” by removing oxidative damage and maintaining mitochondrial quality.
Stacking 5-amino-1MQ with this combination further slows down NAD⁺ loss, stretching out every benefit.
You get:
Prolonged mental clarity
Faster muscle and connective tissue recovery
Better stress resilience
Deeper, more restorative sleep
Higher overall energy—without the crash
What to Expect
Here’s what I have noticed:
More sustained energy throughout the day
Better workout recovery
Improved skin, hair, and nail health (longevity pathways don’t just work inside the cell)
Sharper focus, less brain fog
Enhanced sense of well-being
Fewer “down” days, even during periods of high stress
Most people start noticing these benefits within 2–4 weeks, with effects compounding over time.
Who is a Good Candidate?
Consider NAD Regen if you’re:
Already using or considering NAD⁺ injections (or IV therapy)
Taking oral NAD⁺ precursors (NMN, NR, niacin)
Stacking 5-amino-1MQ and want to maximize efficacy
Training hard, pushing your mental and physical limits
Recovering from illness, high stress, or burnout
Interested in longevity and cellular anti-aging protocols
Dealing with fatigue, poor focus, or slow recovery
Pro tip: If you’re new to NAD+ or 5-amino-1MQ, NAD Regen can help smooth your adaptation and accelerate results.
Ready to Try NAD Regen?
I worked out a deal for my readers. Use this exclusive link for a special discount of $67 off on a 3 pack of NAD Regen:
Best,
Hunter
P.S. You can read verified testimonials on the product by clicking here.
Further Reading & References
NAD⁺ salvage / niacin & copper support
https://pubmed.ncbi.nlm.nih.gov/27374990/ (NAD⁺ metabolism review)
https://pubmed.ncbi.nlm.nih.gov/30782960/ “Niacin: an old lipid drug in a new NAD⁺ dress”
Resveratrol – SIRT1 / AMPK activation & mitochondrial biogenesis
https://pubmed.ncbi.nlm.nih.gov/12939617/ (Small-molecule activators of SIRT1; resveratrol lowers Km for NAD⁺)
https://pubmed.ncbi.nlm.nih.gov/17112576/ (Resveratrol activates SIRT1-PGC-1α, improves mitochondrial function)
AstraGin® botanical components – nutrient-absorption data
https://pubmed.ncbi.nlm.nih.gov/28951595/ (Astragaloside II from Astragalus membranaceus enhances L-arginine uptake & intestinal repair)
Theacrine – non-habituating stimulant & cognitive/energy effects
https://pubmed.ncbi.nlm.nih.gov/35103121/ (TeaCrine® ± caffeine: mood, focus, cognition trial)
https://pubmed.ncbi.nlm.nih.gov/28875060/ (Theacrine + caffeine pharmacokinetic interaction study)
Wasabi isothiocyanates – phase-II detox / Nrf2 pathway
https://pubmed.ncbi.nlm.nih.gov/16614479/ (Allyl-isothiocyanate induces quinone reductase in Hepa1c1c7 cells)
https://pubmed.ncbi.nlm.nih.gov/15053522/ (Plant-derived isothiocyanates induce Phase-II detox enzymes in rats)
https://pubmed.ncbi.nlm.nih.gov/15832810/ (Review of xenobiotic-induced Phase I/II/III metabolism & transport)
Spermidine – autophagy, mitochondrial “house-cleaning,” longevity
https://pubmed.ncbi.nlm.nih.gov/19801973/ (“Induction of autophagy by spermidine promotes longevity”)
https://pubmed.ncbi.nlm.nih.gov/39117797/ (“Spermidine is essential for fasting-mediated autophagy and longevity”)