I Stack This With NAD+ Injections

The final piece of the NAD+ puzzle?

Author

Hunter Williams
July 09, 2025

Happy Wednesday!

Today I want to talk about a combination that’s had a huge impact on my mitochondrial health, energy, and overall sense of drive: injecting NAD⁺ alongside 5-amino-1MQ, and the little-known supplement that has become a personal favorite of mine.

It’s called NAD Regen.

For the last year, I’ve been experimenting with injecting 50–100 mg of NAD⁺, two to three times a week, and stacking it with 1mg per day of injectable 5-amino-1MQ.

The synergy between these two has been nothing short of remarkable:

  • NAD⁺ is the fuel for your cellular engines. It boosts sirtuins, DNA repair, and mitochondrial output.

  • 5-amino-1MQ acts as an NAD⁺ preservation molecule, inhibiting the enzyme NNMT that chews up NAD⁺ and wastes your precious cellular currency.

Together, I felt longer-lasting energy, faster workout recovery, and a sharper, more focused mind. But as anyone in the peptide world knows, there’s always another level…

Intro

Initially, I thought my NAD optimization stack was already maxed out.

But a good friend (fellow peptide fanatic and influencer) messaged me: “Have you tried NAD Regen?”

At first, I brushed it off as another “NAD booster” on the market, right?

I’ve heard that one before!

But when I dug into the ingredient panel, I actually thought there might be something to it.

NAD Regen was built to synergize with NAD⁺ therapy, and every component had a place in the NAD/mitochondrial puzzle.

So, I added NAD Regen to my routine and started popping two capsules alongside my NAD⁺ injections.

Within weeks, the difference was noticeable.

The benefits of NAD⁺ lasted longer.

My energy, mental clarity, and post-workout recovery improved massively.

Why NAD Regen is the Perfect Companion to NAD⁺ (and 5-amino-1MQ)

Here’s what makes NAD Regen such a game-changer:

  • Injectable NAD⁺ gives you a spike, but on its own, those levels can drop quickly.

  • 5-amino-1MQ slows NAD⁺ breakdown, but it doesn’t provide extra building blocks or activate longevity pathways.

  • NAD Regen supplies:

    • Substrates for NAD⁺ recycling (niacinamide/copper)

    • Sirtuin activation (resveratrol)

    • Gut absorption support (AstraGin®)

    • Detox and redox balance (wasabi extract)

    • Autophagy and cellular cleanup (spermidine)

    • Clean energy (theacrine)

Stacking all three is like switching from regular gasoline to rocket fuel. 

Instead of a brief, fleeting peak, you create a sustained, multi-layered support system for cellular energy, repair, and resilience.

The Science

Let’s break down the clinical magic behind each component in NAD Regen, and why it matters:

NAD3® Complex (Wasabi Extract, Theacrine, Cuprous Niacin)

  • Niacinamide is recycled in the salvage pathway, supporting ongoing NAD⁺ synthesis after your injection boost wears off.

  • Copper is critical for cytochrome c oxidase. If your mitochondria are working overtime, copper keeps the wheels spinning.

  • Theacrine offers a smooth, non-habituating energy lift (think: focus without the caffeine crash).

  • Wasabi extract provides isothiocyanates, ramping up your body’s internal detox system and mopping up oxidative stress from fast-paced metabolism.

Resveratrol

  • Activates SIRT1, a longevity enzyme that’s NAD⁺-dependent. With plenty of NAD⁺ on board, resveratrol pushes mitochondrial biogenesis, DNA repair, and healthy aging.

AstraGin® (Astragalus & Panax notoginseng)

  • Proven to increase gut absorption of nutrients, including amino acids and vitamins. When you’re flooding your cells with NAD⁺, you want all the support nutrients to reach peak levels too.

Spermidine

  • A natural autophagy inducer. Think of it as your cellular “clean-up crew,” removing damaged mitochondria and protein junk that build up when you run your engines hot.

The Clinical Efficacy of NAD Regen

On its own, NAD⁺ is like a massive bank deposit, but without NAD Regen, you might spend it all too fast.

Here’s what the clinical evidence tells us:

  • NAD3® gives you a recycling mechanism, not just a single spike.

  • Resveratrol and theacrine help your cells use that NAD⁺ for actual repair and anti-aging, rather than just burning it off.

  • AstraGin® ensures you’re absorbing every last drop of supportive nutrients you ingest, maximizing oral bioavailability.

  • Wasabi and spermidine keep the “system clean” by removing oxidative damage and maintaining mitochondrial quality.

  • Stacking 5-amino-1MQ with this combination further slows down NAD⁺ loss, stretching out every benefit.

You get:

  • Prolonged mental clarity

  • Faster muscle and connective tissue recovery

  • Better stress resilience

  • Deeper, more restorative sleep

  • Higher overall energy—without the crash

What to Expect

Here’s what I have noticed:

  • More sustained energy throughout the day

  • Better workout recovery

  • Improved skin, hair, and nail health (longevity pathways don’t just work inside the cell)

  • Sharper focus, less brain fog

  • Enhanced sense of well-being

  • Fewer “down” days, even during periods of high stress

Most people start noticing these benefits within 2–4 weeks, with effects compounding over time.

Who is a Good Candidate?

Consider NAD Regen if you’re:

  • Already using or considering NAD⁺ injections (or IV therapy)

  • Taking oral NAD⁺ precursors (NMN, NR, niacin)

  • Stacking 5-amino-1MQ and want to maximize efficacy

  • Training hard, pushing your mental and physical limits

  • Recovering from illness, high stress, or burnout

  • Interested in longevity and cellular anti-aging protocols

  • Dealing with fatigue, poor focus, or slow recovery

Pro tip: If you’re new to NAD+ or 5-amino-1MQ, NAD Regen can help smooth your adaptation and accelerate results.

Ready to Try NAD Regen?

I worked out a deal for my readers. Use this exclusive link for a special discount of $67 off on a 3 pack of NAD Regen:

Best,

Hunter

P.S. You can read verified testimonials on the product by clicking here.

Further Reading & References