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- Is Cardarine (GW501516) Safe?
One of our flagship products at BioLongevity Labs is ShredX (which is on sale for 20% right now). It contains the following ingredients:
SLU-PP-332 at 275mcg
Cardarine (GW501516) at 5mg
AOD9604 (Lipotropin) at 100mcg
I love ShredX, but I know I’m slightly biased because it’s from my company.
Yet long before we launched BLL, I was an ardent user and supporter of cardarine (I actually had a comprehensive video about it on my old YT channel, which was deleted).
With the recent launch of ShredX, I’ve been getting many questions about the age-old “cardarine and cancer” studies.
Before I get into the meat and potatoes today, I want to clarify - if you are scared of research peptides and small molecules, DO NOT USE them!
I never encourage anyone afraid of a product to take something they fear.
But for research lab rats like me willing to take relatively small risks with great potential benefits, I am willing to take a leap of faith….ESPECIALLY when much of the data surrounding some of the products I discuss is flawed.
So, let’s dig into the backstory of cardarine and cancer.
The cancer concerns surrounding cardarine stem primarily from a study conducted on mice, where the compound caused tumor growth at extremely high doses.
Here is the backstory on “the study” (which is also hard to find any links or info to):
• Study Summary: A 2007 preclinical study on mice found that Cardarine caused tumors in various organs (liver, stomach, bladder) when administered at very high doses for extended periods.
• Dosage Used: Mice were given doses ranging from 3 mg/kg/day to 40 mg/kg/day.
• Outcome: Tumor formation was observed, particularly at the 40 mg/kg/day dose, over a 2-year period.
Now, let’s do some rough math that equates mouse dosing to human dosing, courtesy of ChatGPT.
What does this mean?
A 70 kg (150lb) human would need to take ~227 mg/day of Cardarine—a dose that is:
More than 10 times higher than the commonly used human dosage (10-20 mg/day).
Far beyond the practical or safe range for human use.
But let’s look at the data on humans (which is also hard to find because GlaxoSmithKline hides it):
Evidence from Human Studies
1. Clinical Trial on Lipid Metabolism (2004):
• A 12-week study on healthy volunteers taking Cardarine showed significant reductions in LDL cholesterol and no adverse effects at doses up to 10 mg/day.
• No cancer or serious side effects were observed.
2. PPAR-Delta Agonists and Cancer:
• PPAR-delta activation by Cardarine promotes fatty acid oxidation and anti-inflammatory effects, which are generally protective against cancer in humans.
• In contrast, chronic overstimulation of PPAR-delta at extreme doses (like in the mouse study) could theoretically increase cell proliferation and tumor growth.
If you dare, put your tin foil hat on for a second.
“Drop in LDL cholesterol”…..Hmmmmm……what other drug is supposed to do that?
Oh yeah - STATINS!
Yes, the same statins that generated $15.9 billion in revenue for big pharma in 2024.
The conspiracy theorist in me thinks that cardarine may have threatened the coffers of the statin overlords, and the rest is pretty much history.
Cardarine was pulled from development and relegated to the research chemical world for biohackers like you and me.
So, is cardarine safe?
I think so.
But use at your own risk.
And who knows, you may improve your lipid profile, physique, strength, and stamina in the process.
Best,
Hunter
P.S. Tomorrow morning at 10 AM EST, my fiance Taylor and I will be doing a live stream podcast talking about all things hormones, peptides, and fitness for optimized couples.
If you want to join, we’ll be answering questions live. Here is the link to RSVP and join.
You can also always hop over to YouTube to watch live tomorrow.
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