Methylene Blue Deep Dive

I do tons of research compiling ideas and info around new video topics every week.

One of the tools I use is called Vidiq, which shows me how many people are searching for any given keyword.

Well, last week, in my planning, I discovered that over 3,700 people per month are searching for “Hunter Williams Methylene Blue”—and I don’t even have a video published on it! 

That’s when I knew it was time to dive deep into everything methylene blue does and why it might be one of the most powerful mitochondrial enhancers available.

So today, we’re breaking it all down.

Here’s the link to the video:

And here’s my written summary of the video.

What Does the Science Say About Methylene Blue?

It’s been used medically since the late 1800s and has applications ranging from neurological enhancement to antimicrobial defense to mitochondrial support.

But how does it actually work?

1. Mitochondrial Function & Energy Production

Methylene blue acts as an electron donor in the electron transport chain, enhancing ATP production. In other words, it directly supports your body’s ability to create energy at the cellular level.

• It enhances ATP production by bypassing complex I and III deficiencies—this makes it particularly beneficial for people dealing with mitochondrial dysfunction.

• It helps counteract oxidative stress—neutralizing free radicals and reducing cellular damage.

2. Cognitive Enhancement & Neuroprotection

Methylene blue also protects the brain.

• Increases oxygen metabolism in the brain—leading to sharper focus, memory, and cognitive function.

• Reduces neuroinflammation and misfolded protein accumulation—a crucial factor in preventing neurodegenerative diseases like Alzheimer’s and Parkinson’s.

• Acts as an MAO inhibitor, increasing serotonin, dopamine, and norepinephrine—making it useful for mood enhancement and cognitive function. But be cautious—do NOT combine with SSRIs, as it can cause serotonin syndrome.

3. Antimicrobial & Antiparasitic Properties

Methylene blue was originally used to treat malaria, and its antimicrobial properties extend beyond parasites.

• Kills bacteria, fungi, and viruses by increasing oxidative stress in pathogens.

• Has been shown to work synergistically with antibiotics—potentially counteracting antibiotic resistance.

4. Cardiovascular Health & Nitric Oxide Modulation

Methylene blue interacts with nitric oxide pathways, which plays a role in blood pressure regulation.

• Inhibits excessive nitric oxide production, making it useful for treating septic shock and low blood pressure conditions. 

• May have cardioprotective effects due to its impact on mitochondrial health and oxidative stress. 

5. Anti-Aging, Longevity & Cellular Repair

It’s also a major player in longevity science.

• Reduces oxidative stress and enhances mitochondrial function—a major factor in slowing down cellular aging. 

• May enhance autophagy and mitophagy, helping the body clear out damaged cells and optimize regeneration.

• Potential anti-cancer properties—certain studies suggest it may reduce tumor size in photodynamic therapy applications.

Should You Use Methylene Blue?

Best Candidates

✅ Those with neurodegenerative diseases (Alzheimer’s, Parkinson’s, MS)

✅ Biohackers looking for cognitive enhancement

✅ Individuals with chronic fatigue syndrome (CFS) or mitochondrial dysfunction

✅ People recovering from brain injuries or concussions

✅ Those in need of antimicrobial, antifungal, and anti-parasitic support

Who Should Avoid It?

❌ People on SSRIs, SNRIs, or MAOIs (risk of serotonin syndrome)

❌ Those with G6PD deficiency

❌ Pregnant or breastfeeding women

❌ People with severe cardiovascular conditions

How to Use Methylene Blue

If you’re ready to try methylene blue, here’s exactly how to dose, stack, and administer it for optimal results.

Step 1: Dosing Guidelines

• Low Dose (5-20mg/day): General cognitive benefits and mitochondrial support.

• Moderate Dose (40-60mg/day): Mitochondrial enhancement and neuroprotection.

• Higher doses may generate reactive oxygen species, so start low and titrate up.

Step 2: Best Stacks for Maximum Effect

✅ For mitochondrial health: SLU-PP-332, SS-31, MOTS-C, NAD+ precursors.

✅ For cognitive function: Injectable L-Carnitine, CoQ10, Alpha Lipoic Acid, PQQ.

✅ For antimicrobial benefits: LL-37, KPV, BPC-157.

Step 3: How to Take It

• Oral (capsules or liquid) or sublingual.

• Topical use for wound healing and skin benefits.

Sourcing?

I just get a brand on Amazon, which you can find on my Amazon Storefront.

Best,
Hunter