New Cagrilintide Studies Out

Happy Tuesday!

If you’ve been following the cutting edge of peptide science, you know things are changing FAST.

And nowhere is this more obvious than in the new data just released this month on the next generation of weight management and metabolic optimization peptides: Cagrilintide.

Because the new clinical trial data, published in July 2025, are showing results that, frankly, blow the doors off everything that’s come before.

Here’s the latest report: https://www.nejm.org/doi/full/10.1056/NEJMoa2502081

We’re talking about weight loss numbers that would have sounded like science fiction five years ago. 

Let’s dig in.

Why the Hype?

Cagrilintide is a long-acting amylin analogue, a synthetic cousin of the hormone amylin, which is naturally secreted alongside insulin by your pancreas.

Amylin’s primary role?

Satiety and blood sugar regulation.

In other words, cagrilintide works by amplifying your body’s natural “I’m full, stop eating” signals and tightening up post-meal blood sugar swings.

But the real magic happens when you combine cagrilintide with GLP-1 agonists like semaglutide or retatrutide.

The Newest Studies

The most recent studies, published just weeks ago in The New England Journal of Medicine, have put cagrilintide to the test in over 4,500 real-world humans.

Here’s the headline: When paired with semaglutide (the combo is nicknamed “CagriSema”), participants lost an average of 20.4% of their total body weight over 68 weeks.

For reference, monotherapy with semaglutide alone produced about 15% weight loss, and cagrilintide alone was about 11-12%.

But the combo was the clear winner.

Even more impressive?

40% of participants on the combo lost 25% or more of their total body weight, which is on par with retatrutide. 

And the side effect profile?

Very tolerable. Mainly the mild GI effects you’d expect with any GLP-1 analog.

This is a sea change in what’s possible for weight management without surgery.

Synergies

Why does cagrilintide work so well when combined with a GLP-1 like semaglutide (or, soon, retatrutide)?

It comes down to how these two classes of peptides interact at the receptor level and, more importantly, what this does to your hunger, satiety, and energy output.

• GLP-1 agonists primarily work by boosting insulin secretion, suppressing glucagon, and slowing gastric emptying, which makes you feel full for longer.

• Cagrilintide acts on the amylin pathway, delivering satiety signals directly to your brain and enhancing your body’s natural meal-stopping cues. It also slows gastric emptying, but via a separate, complementary route.

When you stack them, it’s a double-whammy.

You’re hitting multiple hunger and fullness pathways at once, blunting appetite, smoothing out blood sugar, and reducing food intake in a way that the brain can’t easily adapt to or override.

The result is weight loss that’s faster, deeper, and much more sustainable.

What About Diabetes and Blood Sugar?

The most recent REDEFINE-2 trial specifically studied the combo in people with type 2 diabetes, and the results were equally game-changing.

Over 68 weeks, people taking the cagrilintide/semaglutide combo lost almost 14% of their body weight, compared to just 3% with placebo.

But that’s not all.

Nearly three out of four patients on the combo achieved an HbA1c of 6.5% or less.

And side effects?

Again, nothing new, mainly transient mild GI issues (nausea, constipation, diarrhea), and no increased risk of severe hypoglycemia.

If you’ve tolerated GLP-1s before, you’ll tolerate this.

The Retatrutide Factor

Here’s where it gets really interesting, and why I’m so bullish on this stack.

All of this jaw-dropping synergy is based on combining cagrilintide with semaglutide, a single-agonist GLP-1.

But if you’ve followed my emails, you know the new king of the hill is retatrutide and it’s crushing everything in the weight loss space.

Imagine what happens when you combine cagrilintide with retatrutide. 

If stacking with semaglutide gives you 20%+ weight loss, we’re likely looking at even greater results with a triple agonist.

Early data (from the research community of WE the people) are suggesting a next-level synergy, possibly the most powerful non-surgical intervention ever for fat loss and metabolic rejuvenation.

This is why I’m personally using and recommending cagrilintide as a base for anyone serious about fat loss, whether you’re running semaglutide, retatrutide, or the next generation of GLP-1 combos.

Not All Unicorns and Rainbows

I want to be real with you.

Cagrilintide is not a one-size-fits-all solution.

Many of my readers absolutely love it.

They say it gives them the perfect level of appetite suppression.

It’s enough to feel in control around food, but not so strong that they lose all pleasure from eating.

For these folks, it’s like flipping a switch.

The cravings and constant food chatter in the brain finally quiet down, making it dramatically easier to stick to a nutrition plan and see rapid progress.

But there’s another side to the story.

Some people report that cagrilintide can tip the scale too far, causing a kind of emotional flatness or mild anhedonia. 

It’s not clinical depression, but more of a muted sense of reward.

Not just for food, but sometimes for other everyday pleasures.

If you notice you’re just “meh” about things you usually enjoy, it may be your body’s satiety pathways are being dialed up a little too high.

Listen to your body.

For many, cagrilintide is a game-changer.

For others, adjusting the dose or switching up the stack might be a better fit.

Dosage Protocol

If you’re ready to experiment with cagrilintide, here’s the simple protocol I recommend for most people starting out, especially if you’re sensitive to appetite suppressants or just want to play it smart.

• Start with a 5mg vial of cagrilintide from BioLongevity Labs.

• Reconstitute it by adding 2ml of bacteriostatic water directly to the vial. This will give you a solution where each 0.1ml (10 units on a standard insulin syringe) equals 0.25mg of cagrilintide.

• Begin by injecting 0.25mg (10 units) subcutaneously, 2-3 times per week.

• You can use any standard 1ml (100 unit) insulin syringe; just draw up to the “10 unit” mark for each dose.

• Most people find this is the perfect starting point. Not too much, not too little.

After 2-3 weeks, listen to your body.

If you want more appetite suppression, you can titrate up.

Just add an extra 0.25mg dose per week or increase the dose slightly (always in 10 unit/0.25mg increments).

If you notice any flattening of mood or excessive suppression, back it down.

Final Thoughts

If you’re ready to take advantage of what is honestly the most exciting breakthrough in metabolic medicine of our lifetimes, you can now get cagrilintide from BioLongevity Labs.

And I’ve made sure my readers get the best deal anywhere:

• 20% off Cagrilintide (automatically applied at checkout)

• PLUS an extra 15% off when you use code HUNTERW at checkout

In summary, cagrilintide may be the “secret sauce” that unlocks next-level results from your GLP-1 regimen.

The latest clinical data don’t lie.

We’re seeing more weight loss, better metabolic health, and no new safety concerns.

If you’ve tried GLP-1s before and felt “meh” about the results, this is the missing link you’ve been looking for.

Best,

Hunter Williams