Happy New Year!
I hope you are enjoying the first day of 2026. More importantly, I want to wish you and your loved ones a healthy and prosperous 2026!
Before my lift today, I was looking through my pantry, deciding which injectable pre-workout to use.
I had an unmixed bottle of VIP and hadn’t used any in a while, so I decided to mix it up and inject 100mcg this morning before my workout.
I had an incredible workout, and it reminded me just how powerful and versatile VIP is.
More importantly, it’s a peptide so few people have heard of, let alone experienced.
When I dig into the research, I always ask myself:
How is this one peptide showing up in lung research, vascular research, migraine research, gut inflammation research, and even mood/brain imaging papers?
VIP is more like a systems peptide.
It affects blood vessels, smooth muscle, immune signaling, and neurovascular tone in ways that show up across very different categories of human data.
Today, inspired by my workout this morning, I will go over the many benefits of VIP.
FYI, Until Sunday January 4th at Midnight PST, BioLongevity Labs is offering 40% off all products. You can get an additional 15% off when you use code HUNTERW at checkout.
Lungs
VIP has been studied in humans with pulmonary hypertension, where it demonstrated effects on pulmonary hemodynamics and oxygen exchange.
This matters because it confirms that VIP directly influences blood flow inside the lungs, not just airways.
That’s why many people subjectively notice:
Easier breathing
A feeling of the chest “opening”
Reduced air hunger
Blood Flow
Human physiology studies show that VIP produces dose-dependent vasodilation in the skin through nitric oxide and histamine-related pathways.
This leads to increased blood flow, which makes it similar to Cialis, Viagra, and your favorite pre-workout supplements.
Nervous System
One of the most overlooked human findings with VIP is its relationship to autonomic balance.
VIP is heavily involved in parasympathetic signaling, which aligns with the subjective effects many people report:
Calm without sedation
Less internal “noise”
Easier emotional regulation
Anxiety/Depression
A human study measuring plasma VIP levels found that higher VIP concentrations were associated with:
Lower anxiety scores
Lower depression scores
Measurable differences in brain connectivity related to emotional regulation
Remeber, as always, correlation ≠ causation.
But it strongly supports why VIP feels calming for the right person, and why it’s often described as mentally grounding.
Gut-Immune Signaling
Human studies in inflammatory bowel disease have shown that plasma VIP levels increase during active disease.
This doesn’t mean VIP is a direct treatment for IBD.
It means VIP is part of the gut-immune communication system in humans, especially during inflammation.
This explains why VIP helps reduce:
Mast cell activation
Gut-driven inflammation
Systemic immune dysregulation
Immune System
Across human research contexts, VIP consistently behaves as an immunomodulator, not an immunosuppressant.
It doesn’t shut the immune system down.
It doesn’t stimulate it aggressively.
It rebalances immune signaling, especially at the interface between inflammation, vascular tone, and nervous system input.
That’s a rare combination.
Systems-Wide Benefits
When you zoom out, the most important benefit of VIP isn’t any single effect.
VIP influences vascular tone, immune tone, pulmonary tone, and nervous system tone simultaneously.
Very few peptides do that.
That’s why VIP can feel incredible for the right person.
Dosage and Reconstitution
Here’s how I like to dose VIP.
Vial: 5 mg VIP (5,000 mcg)
Add: 3.0 mL bacteriostatic water
Final concentration:
5,000 mcg ÷ 3.0 mL = 1,666 mcg per mL
Using a U-100 insulin syringe:
50 mcg = 0.03 mL = 3 units
100 mcg = 0.06 mL = 6 units
Most people should start at 25–50 mcg, assess response, then decide whether 100 mcg is appropriate.
Most likely you will get flushing and a slight increase in heart rate within 10-15 minutes of injecting (similar to oxytocin), so just know that’s a completely normal response.
Final Thoughts
VIP tends to work best for people who:
Have inflammatory or autonomic lung symptoms
Feel chronically stuck in sympathetic mode
Have systemic inflammation without clear infection
Respond well to parasympathetic-leaning interventions
With VIP, breathing becomes easier, circulation improves, inflammation subsides, and the nervous system shifts out of constant overdrive.
When used correctly and dosed appropriately, VIP tends to feel less like adding another tool and more like restoring the regulatory signals the body has been missing.
Best,
Hunter Williams
P.S. VIP is also on sale at BioLongevity Labs for 40% off, plus an additonal 15% off when you use code HUNTERW at checkout.
Further Reading