Peptide Purity Deep Dive

If you’ve been diving into the peptide world, you’ve probably heard some chatter about something called LPS—or lipopolysaccharides—and whether or not they are lurking in your research peptides.

It’s a question I’ve been getting a lot lately, and for good reason.

There’s been a lot of confusion (and misinformation) going around, especially from people who don’t fully understand how peptides are made or tested.

Here’s an example of a question I recently got:

I get where this comes from.

The thought of injecting something you ordered from a random website online with harmful contaminants is scary to most folks.

So, do research peptides contain LPS or other contaminants?

My new YouTube video goes in-depth on this very topic.

But if you don’t have time to watch the video, here’s a written explanation.

What Are LPS (and Why Are People Scared)?

Lipopolysaccharides (LPS) are molecules found in the outer membranes of certain bacteria. They can trigger a significant immune response if they enter your body.

LPS, in large amounts, can contribute to issues such as inflammation, leaky gut, and chronic health conditions.

So, the fear that peptides might be contaminated with LPS isn’t entirely irrational—it’s a valid concern if your supplier isn’t reliable.

But here’s the catch: The idea that “all peptides from gray-market suppliers contain LPS” simply isn’t accurate.

How Does LPS Get Into Peptides?

The truth is that contamination can happen during manufacturing if the lab doesn’t follow proper protocols. For example:

• Bacterial contamination: Peptides are often synthesized in systems like E. coli, and poor purification could leave behind bacterial remnants like LPS.

• Bad lab practices: Contaminants can slip through if equipment or containers aren’t appropriately sterilized.

• Low-quality raw materials: Sourcing from unregulated suppliers can introduce impurities.

But this is where reputable manufacturers stand apart—they use strict purification processes and adhere to good manufacturing practices (GMP).

How to Make Sure Your Peptides Are Clean

This is where you, as a buyer, MUST do your homework.

The best way to verify peptide purity is by reviewing the Certificate of Analysis (COA) provided by the supplier.

A trustworthy COA will include:

• Endotoxin levels: This measures how much LPS might be present. Levels under 10 EU/mg (endotoxin units per milligram) are generally considered safe.

• HPLC testing: High-Performance Liquid Chromatography confirms peptide purity. Look for a purity level of 98% or higher (99% is even better).

• Mass spectrometry: This ensures the molecular weight matches what the peptide is supposed to be, ruling out unexpected contaminants.

For example, if you’re reviewing a COA and see:

• Endotoxins: <10 EU/mg ✅

• Purity: 99%+ ✅

• Molecular weight: Matches the label ✅

Generally speaking, you’re good to go.

Red Flags to Watch Out For

Not every supplier is upfront about their testing, and that’s a huge warning sign.

If a company can’t—or won’t—provide a COA, that’s a dealbreaker.

Another red flag?

And remember, while GMP compliance is essential, third-party testing adds an extra layer of confidence.

A good supplier will test their products in-house and send them to an independent lab to confirm their quality.

The Real Problem: Fear-Mongering

Let’s shift gears for a moment and talk about why this topic even comes up in the first place.

There’s much fear-mongering in the health and wellness space, especially around peptides.

You’ve probably heard influencers or “experts” claim that all research peptides are dangerous or that anything not from a compounding pharmacy is contaminated.

Why do they say this?

Often, it’s because they have something to sell—whether that’s pharmaceutical alternatives or another product entirely.

I don’t even fault them for attempting to sell products (shoot, I sell or recommend tons of things to buy).

But do your homework and know why they have the viewpoint they do.

When you take the time to verify your sources and understand what to look for in a COA, peptides are not only safe but also incredibly effective.

If you’re feeling overwhelmed by the technical side of peptides, don’t worry—that’s normal. It’s a lot of information, especially if you’re new to the space.

As always, check out some of the resources I have:

• The Peptide Cheat Sheet: A quick guide to understanding and using peptides safely. Download it here.

• Fully Optimized Health Community: Join the best community for peptides, biohacking, and hormone optimization. Learn more here.

If you’re serious about using peptides as a tool (not a crutch), these resources are a great place to start.

Additionally, remember to check out BioLongevity Labs (we should be back in stock with several items by next week).

As always, my heart overflows with gratitude for your support!

Best,

Hunter