Retatruitde + Cagrilintide

FYI, I just dropped a new YouTube video today about MOTS-c vs. SS-31 if you want to check it out.

You’ve probably heard me rave non-stop about retatrutide aka GLP-3, the groundbreaking triple-agonist peptide that’s completely reshaping the fat-loss landscape.

But lately, I’ve received some messages asking:

Great question. Let’s get straight into it.

Why You Might Still Feel Hungry (or Even Hungrier) on Retatrutide

First, let’s revisit what retatrutide does.

It’s arguably the most potent fat-loss peptide we’ve ever seen, simultaneously activating three crucial metabolic pathways:

• GLP-1 receptors: Powerfully suppress hunger, slow digestion, and help stabilize blood sugar.

• GIP receptors: Improve insulin response and nutrient partitioning, enhancing your body’s metabolic flexibility.

• Glucagon receptors: Boost energy expenditure, revving up fat burning, and mobilizing stored body fat for fuel.

This triple action usually crushes appetite and accelerates fat loss.

But here’s the surprising catch: sometimes glucagon receptor activation can temporarily make you feel hungrier.

Here’s why:

1. Glucagon Receptor Activation & Reactive Hunger

Glucagon signals your body to ramp up energy expenditure.

While this is awesome for fat burning, it can create short-term increases in hunger.

Why? Because your body is suddenly burning through calories at a faster rate, your brain senses a deficit and triggers hunger signals, essentially yelling, “Hey, feed me—I’m burning calories rapidly here!”

This reactive hunger spike can feel frustrating because you’re supposed to feel less hungry, yet your metabolism is firing on all cylinders, urging you to eat more.

2. Rapid Fat Loss & Hormonal Counter-Regulation

When you lose fat quickly—something retatrutide excels at—your body senses rapid calorie deficits as an emergency.

It kicks in survival mechanisms, increasing hunger hormones like ghrelin to protect you from losing too much stored energy.

You end up with hunger spikes as your body tries to maintain its comfortable fat-storage equilibrium.

3. Reduced Meal Size, More Frequent Hunger

Retatrutide slows gastric emptying and reduces portion sizes significantly.

But smaller meals may sometimes lead to increased hunger frequency.

Your body expects meals more often, prompting cravings or hunger signals between smaller feedings.

4. Psychological & Emotional Hunger

Retatrutide superbly suppresses physiological hunger, but emotional, habitual, or reward-driven cravings (think comfort eating, stress-induced snacking, or boredom) might still slip through.

In fact, with your physical hunger minimized, emotional hunger can suddenly feel amplified because your brain is seeking satisfaction through comfort foods or habitual snacking.

This is exactly where cagrilintide comes into the equation and absolutely shines.

Retatrutide vs. Cagrilintide: What’s the Difference?

Let’s break these two peptides down clearly:

• Retatrutide:

  A powerful triple-action peptide targeting GLP-1, GIP, and glucagon pathways.

• Cagrilintide:

  A potent, long-acting amylin analogue. Amylin is a natural hormone your pancreas produces alongside insulin, telling your brain: “I’m full—let’s put down the fork.” Cagrilintide dramatically amplifies fullness signals, especially helpful for tackling emotional eating, food cravings, and habitual overeating.

Comparing & Contrasting Clearly:

• Retatrutide provides broad-spectrum metabolic benefits, increasing calorie burn and metabolic flexibility.

• Cagrilintide zeros in strictly on appetite suppression, particularly emotional and reward-driven eating.

Combined, these peptides form a powerhouse synergy, delivering both deep metabolic benefits and extreme hunger control.

Who Benefits Most From Combining Retatrutide + Cagrilintide?

This is where things get really exciting.

Most peptides or medications target either severe obesity or ultra-fit individuals separately. But the retatrutide-cagrilintide combo spans the entire spectrum, benefiting:

• Clinically obese individuals: Clinical trials reveal combinations like this can achieve staggering 20-30% total body weight loss—results previously exclusive to bariatric surgery.

• Healthy, lean individuals & biohackers: Those chasing optimal leanness benefit immensely by achieving ultra-low body fat without the typical misery of hunger and cravings that accompany intense dieting.

Why These Two Peptides Are a Perfect Match:

1. Complementary Hunger Suppression:

Retatrutide tackles broad physical hunger, while cagrilintide specifically targets emotional and reward-based cravings that retatrutide alone might miss.

2. Double Gastric Emptying Control:

Both peptides significantly slow digestion, enhancing fullness and naturally reducing meal frequency and size.

3. Enhanced Metabolic Flexibility:

Retatrutide’s glucagon activation ramps up fat oxidation, while cagrilintide further reduces calorie intake by strongly suppressing appetite. This double-team ensures maximum fat utilization and minimal hunger.

My Personal Dosing Protocol:

Through meticulous experimentation on myself, I’ve refined the ideal ratios for combining retatrutide and cagrilintide, calibrated precisely to your hunger-control needs without causing nausea or excessive fullness:

• 4:1 Ratio (Retatrutide : Cagrilintide)

  Perfect for subtle, extra hunger control. If retatrutide alone nearly covers your hunger but leaves slight cravings, this ratio is ideal.

  My Current Protocol: I personally love the 4:1 ratio because it perfectly manages hunger on non-training fasting days, while still letting me comfortably eat and fuel on heavy lifting days. Zero nausea, perfect hunger balance.

• 2:1 Ratio (Retatrutide : Cagrilintide)

  Delivers significantly stronger hunger suppression. If you’ve tried retatrutide alone but still struggle with consistent cravings or emotional snacking, this ratio hits the sweet spot—powerful but manageable.

• 1:1 Ratio (Retatrutide : Cagrilintide)

  This is your “big gun” for extreme cases—serious hunger struggles, compulsive eating, or stubborn food addictions. Cravings nearly vanish, and hunger signals become minimal.

  Important Note: This ratio can increase nausea or discomfort, so use responsibly, and maintain proper electrolyte and protein intake.

Right now, the 4:1 ratio is my ideal choice.

It provides perfect hunger management, keeping my training and fasting routine effortless, and it’s been an absolute game changer for achieving and maintaining peak body composition.

Final Thoughts

The retatrutide + cagrilintide combination is genuinely revolutionary, bringing benefits across the spectrum—from clinical obesity reversal to fine-tuned body recomposition for advanced biohackers.

Used responsibly, it can finally make dieting feel like not dieting at all, putting your fat-loss journey on autopilot and unlocking unprecedented physique optimization.

Best,

Hunter

P.S.Quick reminder: today’s your last chance to save 30% on both retatrutide and cagrilintide at BioLongevity Labs. Just enter code HUNTERW at checkout. Don’t miss this final day of the Fat Loss Sale—your easiest fat-loss season ever begins right now.