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- Tesofensine Is A Wild Card
Happy Monday!
Tesofensine.
Some people love it.
Some people hate it.
I personally love it and keep it in my arsenal for appetite suppression and cognitive enhancement.
I recently received this question in my question box and in light of BLL closing out their tesofensine inventory, I thought it would be appropriate to answer.
“I love Tesofensine. I also take DTE. So I usually take those two 1 hr apart with no food. Do you cycle Tesofensine? Do you cycle oral peptides in general? Do you cycle bioregulators? Thank you.”
Not only is this a great question, but it cuts right to the heart of how to use some of the most potent (and underappreciated) research chemicals and peptides out there.
So today, I’m dedicating this email to Tesofensine, the fat-loss “cheat code” that most people have never heard of, but should.
We’ll cover the history, how it works, what the human research actually shows, and my recommendations for use.
The Forgotten History of Tesofensine
Tesofensine didn’t start life as a weight-loss drug.
In fact, it was originally developed in the late 1990s by a Danish pharmaceutical company as a treatment for neurodegenerative diseases like Alzheimer’s and Parkinson’s.
But what caught researchers’ attention wasn’t cognitive improvement.
It was that patients started dropping pounds, often without even trying.
This unexpected “side effect” set off a flurry of new studies.
Unlike so many other “weight loss” agents that barely move the scale, Tesofensine produced dramatic, sustained fat loss in clinical trials.
Yet, for reasons we’ll get into later (spoiler: pharma politics and regulatory hurdles), it never received FDA approval and mostly fell off the radar…except for a handful of biohackers and forward-thinkers who kept the torch burning.
It’s the classic story.
Big Pharma chases the big fish, while the underground finds the real gems.
Mechanism of Action
So what is Tesofensine, mechanistically?
Unlike your run-of-the-mill antidepressants (SSRIs), which only target serotonin, Tesofensine is what’s called a “triple monoamine reuptake inhibitor.”
Translation: It blocks the reuptake (breakdown and recycling) of dopamine, norepinephrine, and serotonin all at once.
This is a big deal.
Why?
Dopamine helps drive motivation, focus, and that “get up and move” feeling.
Norepinephrine ramps up metabolic rate and keeps your energy high.
Serotonin manages satiety and satisfaction.
By enhancing all three, Tesofensine creates a unique “neurochemical signature” that squashes hunger, boosts mood, and makes you actually want to move.
That’s a totally different ballgame from SSRIs, which often blunt motivation, sap libido, and cause weight gain over time.
What The Studies Show
In the landmark TIPO-1 trial (Lancet, 2008), researchers gave Tesofensine to 203 obese adults for 24 weeks.
The results?
Average weight loss in the high-dose group was over 12 kg (26 lbs), more than double what leading prescription fat-loss drugs achieved, and without extreme dieting or excessive cardio.
Even at the lowest dose, people lost more than twice as much weight as placebo.
But it gets better.
The studies also showed significant body fat reduction, improved appetite control, and better energy levels.
Follow-up studies demonstrated continued weight loss up to 48 weeks and maintained satiety, meaning people kept the weight off more easily than with standard diets or drugs.
Most common side effects? Dry mouth and occasional insomnia.
Nothing like the list of scary warnings you see on most pharmaceutical commercials.
What Can You Expect When You Use Tesofensine?
Here’s what you can actually expect if you start using Tesofensine (and I’m basing this on both the studies and real-world reports):
Substantial Fat Loss: Most people see at least 10–12 pounds in the first two months, sometimes much more, especially if you’re eating even somewhat clean.
Crushed Hunger and Cravings: Suddenly, you can say “no” to that late-night snack and not even care.
Motivation to Move: Most users report a kind of “background energy” and willingness to be more active.
Stable Mood: Unlike stimulant-based fat burners, Tesofensine rarely causes jitters or anxiety. If anything, it can subtly boost mood.
Sustained Results: Even after discontinuing, studies show that people often keep a significant portion of the weight off, likely due to “resetting” appetite circuits.
That’s about as good as it gets in the world of weight management, without resorting to amphetamines, surgery, or unsustainable crash diets.
Who Is (And Isn’t) a Good Candidate for Tesofensine?
Now, let’s be clear: Tesofensine isn’t for everyone. Here’s who I think makes a good candidate:
Men and women with at least 20–30 pounds to lose, or anyone who’s stuck at a plateau with other approaches.
People who struggle with food cravings or appetite regulation.
Those who have tried traditional methods (diet/exercise) and are looking for a more effective adjunct.
Biohackers and advanced users who want to experiment with cutting-edge neuropharmacology.
Folks cycling off GLP-1s but want to keep the appetite suppression momentum going.
Who should avoid it?
Anyone with uncontrolled high blood pressure, severe cardiovascular disease, or arrhythmia.
Those prone to anxiety, mania, or untreated psychiatric conditions.
Pregnant or breastfeeding women (obviously).
People on other serotonergic drugs or strong stimulants (risk of serotonin syndrome).
People using methylene blue (risk of serotonin syndrome).
Always check with a qualified provider before adding Tesofensine or any neuroactive compound to your regimen.
Dosing Recommendations
Okay, let’s get to the nuts and bolts. My standard protocol for Tesofensine is:
250 mcg (0.25 mg) daily
Take first thing in the morning, at least one hour before food (to maximize absorption and minimize GI side effects).
Run for 8 weeks on, then 8 weeks off. This cycling helps prevent tolerance, maintains sensitivity, and keeps the long-term side effect profile in check. (If you want to extend, take at least as much time off as you’re on.)
As for oral peptides and bioregulators in general, yes, I cycle everything.
The body will always adapt, so cycling prevents diminishing returns and keeps you sensitive to the effects.
Eight weeks on/eight weeks off is a solid starting point for almost any oral peptide or bioregulator.
Track your results, and adjust as needed.
Final Thoughts
If you’ve read this far, I want to reward you: BioLongevity is officially closing out our current inventory of Tesofensine.
Right now, you can grab it for 35% off the regular price. PLUS, you can stack my personal code HUNTERW for an additional 15% off at checkout.
This is literally the best price you’ll see anywhere, and it’s only available until we run out.
If you’ve been waiting to try the most potent oral weight loss products out there, now is the time.
Further Reading and Study Links
If you want to dive deeper (and you should), here are the human clinical studies and reviews I referenced:
And as always, stay lean, stay sharp, and stay curious.
Best,
Hunter Williams