The Peptide Stack for Lung Health

Happy Friday!

I just dropped a brand-new episode on Spotify breaking down my favorite peptides for lung health.

This one is personal for me.

Earlier this year, my father-in-law spent about a week in the hospital with what they essentially labeled COPD. When he came home, I put him on the exact stack I’m going to share in this email…and his recovery was insanely fast compared to what you’d expect for that kind of diagnosis.

For context, chronic respiratory diseases were the 3rd leading cause of death globally in 2019 (about 4 million deaths and 454 million cases). That was before COVID.

Standard lung treatments mostly manage symptoms, and they rarely reverse damage.

So, in the new Spotify video (and in this email), I zoom in on five essentials for lung health.

As always, this is not medical advice. This is me sharing what I’ve seen in the real world, plus the data we have so far.

Strap up and let’s break them down.

Bronchogen

First up is Bronchogen, which is the most lung-specific peptide in this stack.

It’s a bioregulator peptide derived from bronchial tissue.

It’s built off the signaling molecules your lung tissue already uses to tell itself how to grow, repair, and behave.

What makes Bronchogen wild is the mechanism. These injectable bioregulators actually penetrate lung cells, get into the nucleus, and bind to DNA and histone proteins.

That changes which genes are turned up or turned down.

In damaged or aged lungs, Bronchogen up-regulates developmental transcription factors and repair programs, so the lung starts expressing a more youthful, less inflamed code.

From a lung-health perspective, I like Bronchogen because it does two things at once:

1. Restores structure – repairs bronchial epithelium, boosts surfactant protein B, and increases secretory IgA for better local immune defense.

2. Calms inflammation – drops TNF-α and IL-6, lowers neutrophil infiltration, and normalizes the immune environment.

Dose I like in this stack:

2 mg injected daily for 12 weeks.

Think of Bronchogen as the “DNA upgrade” for the architecture of the lungs.

Chonluten

Next up is Chonluten, another lung-specific bioregulator peptide, but with a slightly different flavor.

It’s a tripeptide derived from bronchial mucosa.

Mechanistically, it’s very similar to Bronchogen.

It also works at the epigenetic level, normalizing gene expression in the bronchial mucosa, but its superpower is immune modulation.

Chonluten triggers STAT1 phosphorylation and inhibits STAT3 activation.

Essentially, it biases immune signaling toward resolving inflammation rather than chronic, destructive pathways.

In simple terms, it tells the immune system in your lungs, “Hey, stop burning the house down to kill the mouse.”

Why I love it for lung health:

• It dramatically blunts TNF-α, IL-6, and IL-17 release in LPS-activated immune cells – those are big inflammatory cytokines that drive lung damage.

• It reduces white blood cell adhesion to activated endothelium, resulting in fewer inflammatory cells trafficking into already-inflamed lung tissue.

• It up-regulates antioxidant defenses while suppressing enzymes like COX-2 that drive chronic inflammation and fibrosis.

So if Bronchogen is rewriting the structural blueprint, Chonluten is rewiring the local immune response in the lungs.

Dose in this stack:

2 mg injected daily for 12 weeks.

Together, Bronchogen + Chonluten give you a one-two punch. Structural regeneration + immune normalization directly in lung tissue.

VIP

If there’s one peptide in this stack that has real clinical data in humans, it’s VIP(Vasoactive Intestinal Peptide).

VIP hits three major levers for lung health:

1. Bronchodilation – It relaxes airway smooth muscle and opens up breathing passages. For someone like my father-in-law, who literally could not get air in, this is massive.

2. Vasodilation – It dilates pulmonary blood vessels, improving oxygen delivery and lowering pulmonary pressures.

3. Immunomodulation – It acts like a brake on runaway inflammation, promoting regulatory T-cells and reducing pro-inflammatory cytokines (TNF-α, IL-6, etc.).

We have Phase 2 human data showing inhaled or nebulized VIP is safe and well tolerated, with significant reductions in TNF-α and increases in regulatory T-cells in lung fluid.

It’s been looked at in sarcoidosis, PAH, COPD, and even as an emergency-use agent in COVID for cytokine storm and ARDS-type situations.

Dose in this stack:

100 mcg per day for 12 weeks, either as a nasal spray or via injection.

VIP is the “clinical anchor” of this stack.

TB-500

Most people hear the name TB-500 and think of injury repair.

But remember, Thymosin Beta-4, the parent molecule, is found in lung tissue too.

TB-500 is a synthetic fragment of Thymosin Beta-4, a 43-amino-acid peptide that orchestrates wound healing. In the lungs, TB-500 supports:

• Cell migration – binds actin so epithelial cells can efficiently cover damaged airway surfaces.

• Angiogenesis – helps form new capillaries in damaged areas, restoring blood flow.

• Anti-inflammatory signaling – reduces cytokine production and modulates NF-κB.

• Anti-fibrotic action – inhibits TGF-β–driven myofibroblast activation so you get repair instead of scar tissue.

In bleomycin-induced IPF mouse models, Thymosin Beta-4 basically halted the inflammatory process and significantly reduced lung scarring.

Lungs showed fewer inflammatory cells, less collagen deposition, and better structure.

It’s also been helpful in acute lung injury models, improving oxygenation and reducing edema.

Dose I like here:

2 mg injected daily for 12 weeks.

TB-500 helps the lungs heal clean instead of laying down permanent scar tissue.

GHK-Cu

Last but not least, GHK-Cu.

Most people know it for skin, hair, and cosmetic uses, but the more I dig into the data, the more I see it as a legit lung-repair peptide, especially for emphysema and smoke-damaged lungs.

GHK-Cu is a natural tripeptide that binds copper and affects expression of thousands of genes. In lungs, it:

• Activates Nrf2 – ramping up antioxidant defenses and glutathione production.

• Down-regulates NF-κB – reducing inflammatory gene expression.

• Improves MMP-9/TIMP-1 balance – crucial for preventing connective tissue breakdown.

• Stimulates collagen and elastin synthesis – helping restore the elasticity of lung tissue.

In cigarette-smoke-exposed mice, GHK-Cu attenuated emphysema, preserved alveolar structure, dropped IL-1β and TNF-α, and improved antioxidant capacity.

Gene-expression analyses suggest it literally reverses the emphysema-type signature in lung tissue.

Dose in this stack:

2 mg injected daily for 12 weeks.

So if Bronchogen and Chonluten are rewriting lung DNA locally, GHK-Cu is like a global gene-reset signal that tilts the entire system away from degeneration and toward rebuilding.

Stack Summary & Dosing

Here’s the full protocol in one place so you can screenshot or save it:

In my father-in-law’s case, we ran this structure for about 12 weeks.

I’m not saying it’ll magically cure everyone, but the change we saw in that time frame was dramatic.

Final Thoughts

All of this is experimental. I’m just a guy on the internet who loves reading studies and has seen this work in real people, including my own family.

You still have to take responsibility, do your own research, and work with a smart clinician.

If you want the full visual and walk-through, go listen to the new episode on Spotify where I go slide-by-slide through this stack and the data behind it.

Thank you for being here, for caring enough to learn this stuff, and for supporting the work I do. Without you, none of this exists!

Best,

Hunter Williams

Further Reading

• Bronchogen

• Chonluten

• VIP

• TB-500

• GHK-cu