Why GLP-1 Microdosing is the Future

If you’re using a GLP-1 peptide like Retatrutide, Tirzepatide, or Semaglutide, or you’ve been thinking about it… you’re probably doing it wrong.

Yep, I said it.

Not because the peptides don’t work (they do). But because the way they’re prescribed—weekly injections—is a disaster waiting to happen.

Most people experience unnecessary nausea, fatigue, muscle loss, and metabolic crashes just because they follow the big pharma playbook of “one massive injection per week.”

But here’s the thing…

There’s a better way—and it’s called GLP-1 microdosing.

Watch the full breakdown in my latest video:

Let me walk you through why microdosing GLP-1s is superior, how it eliminates side effects, and why this simple tweak could completely change your experience with these peptides.

Why Weekly GLP-1 Injections Are a Bad Idea

First, let’s talk about why pharmaceutical companies push weekly injections.

• Convenience: It’s easier to get the average patient to inject once per week instead of multiple times.

• Half-Life Justification: GLP-1s like Retatrutide have a half-life of ~7 days, so pharma companies assume one large dose will keep blood levels stable.

• Compliance: The fewer times a patient has to remember an injection, the higher the likelihood they’ll stick with it.

Makes sense, right?

Wrong.

Here’s why weekly dosing is actually a terrible idea for anyone who wants to optimize their fat loss, metabolic health, and longevity.

The Side Effects of Weekly Injections

❌ Nausea, vomiting, and dizziness

• The huge spike in GLP-1 levels after a weekly injection is like a shockwave through your system.

• Your brainstem, gut, and metabolic pathways get overwhelmed.

❌ Hunger Crashes & Rebound Eating

• After your weekly dose, GLP-1 levels skyrocket, then crash a few days later.

• This creates a yo-yo effect on appetite, leading to extreme hunger and overeating later in the week.

❌ Muscle Loss & Performance Decline

• The peak appetite suppression around days 3-4 makes it hard to eat enough protein and calories.

• If you’re training hard, this can lead to muscle breakdown, low energy, and poor recovery.

❌ Energy Rollercoaster

• High-dose injections cause glucose swings, insulin fluctuations, and autonomic nervous system stress.

• Translation? Poor sleep, low HRV, fatigue, and crashes.

Simply put:

One massive dose per week = unstable blood levels = massive side effects.

So… what’s the solution?

Microdosing: The GLP-1 Hack That Changes Everything

Instead of one huge weekly injection, you split your total dose into three to four smaller injections per week.

Example Protocol:

• Instead of 2mg Retatrutide once per week…

• You inject 0.5mg every other day (Monday, Wednesday, Friday, Sunday).

This method:

✅ Keeps blood levels stable

✅ Reduces side effects (nausea, dizziness, hunger swings)

✅ Allows for better appetite control

✅ Enhances glucose regulation & fat loss

✅ Prevents metabolic crashes & muscle loss

You still get all the benefits—but without the nasty side effects.

Think of it like this:

Weekly dosing = riding a roller coaster (big spikes & crashes)

Microdosing = cruising in a luxury car (smooth & steady)

Which one would you rather be on?

How to Microdose GLP-1s (Dosing Strategy)

Here’s how to set up your microdosing protocol:

For a 2mg weekly dose of reta:

➡️ Inject 0.5mg every other day (Monday, Wednesday, Friday, Sunday).

For a 4mg weekly dose (DO NOT START THIS HIGH!!!):

➡️ Inject 1.3mg 3x per week.

For a 6mg weekly dose (YOU SHOULD ONLY BE ON THIS HIGH OF A DOSE AFTER PROLONGED USE OF 18-24 WEEKS+):

➡️ Inject 2mg 3x per week.

This keeps your blood levels steady, eliminates side effects, and maximizes benefits.

If you’re experiencing:

⚠️ Inconsistent appetite suppression

⚠️ Hunger swings & rebound eating

⚠️ Nausea, fatigue, or dizziness

Microdosing will fix that.

Why This Works (Science of Half-Life & Blood Levels)

Weekly injections create massive peaks and troughs in drug concentration.

Microdosing smooths out these fluctuations so your system stays in a stable, optimal range.

Here’s the kicker:

• With microdosing, your peak serum concentration is LOWER than with weekly dosing.

• This means fewer side effects and a longer-lasting, more effective response.

• It also reduces the risk of antibody buildup, allowing you to use GLP-1s longer without dose escalation.

Bottom line?

👉 Microdosing allows you to stay on a lower dose for longer and get the same (or better) benefits with fewer side effects.

Final Thoughts

The more we study GLP-1s, the more obvious it becomes:

✅ Once-weekly injections are outdated.

✅ Microdosing is the future for anyone serious about fat loss, metabolic health, and longevity.

If you’re currently on a GLP-1, or you’re thinking about starting one, this one small tweak could completely change your experience.

If you found this helpful, forward it to a friend who needs to hear this.

Best,

Hunter Williams

P.S. BioLongevity Labs is offering 15% off the following peptides below; no coupon is needed.

• BPC-157

• TB-500

• Epitalon

• Ipamorelin

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The flash sale ends tonight at midnight PST.

P.P.S

Taylor and I will be live at 10 AM EST tomorrow morning for our coffee talk. Come join us as we answer your most pressing questions!