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- Why NAD+ Might Not Work
If you’ve been injecting NAD+ and the results have been subpar, you’re not alone.
A lot of people are frustrated when they drop money on NAD+ injections, expecting limitless energy, mental clarity, and fat loss—only to end up feeling… meh.
So what’s the deal?
NAD+ by itself may actually not be enough.
Why?
A nasty little enzyme called NNMT (Nicotinamide N-Methyltransferase).
This enzyme is quietly siphoning away your precious NAD+ like a corrupt government skimming off tax revenue.
And unless you stop it, you might be throwing money at your NAD+ injections and hoping for the best.
The good news? There’s a way to stop this NAD+ thief in its tracks and finally unlock the full potential of your NAD+ therapy.
The answer? 5-Amino-1MQ.
For some people, it may be the missing piece that makes NAD+ work as it should.
Let’s dive in.
Why Most People Don’t Get Results from NAD+ Injections
By now, you probably know that NAD+ is essential for energy, metabolism, and cellular repair.
It fuels your mitochondria, helps fix DNA damage, and even regulates aging through a family of proteins called sirtuins.
So in theory, injecting NAD+ should turn you into a fat-burning, brain-boosted, age-reversing machine, right?
Well… not exactly.
Because here’s what most people don’t know:
1️⃣ Your body naturally destroys NAD+ faster than you can replace it.
2️⃣ NNMT is actively working against you by shutting down NAD+ recycling.
3️⃣ Even if you inject high doses, much of it gets wasted if NNMT is running wild.
NNMT is an enzyme that methylates nicotinamide (a key NAD+ precursor), rendering it useless for NAD+ production.
This means even if you inject 100mg, 200mg, or more of NAD+, your body is still struggling to hold onto it.
This is why some people say “NAD+ injections don’t work for me.”
It’s not that NAD+ is ineffective—it could be that NNMT levels are sky-high, and they’re blocking your body from using NAD+ properly.
This is where 5-Amino-1MQ changes everything.
What is 5-Amino-1MQ and Why Is It a Game-Changer?
5-Amino-1MQ is a small molecule NNMT inhibitor.
Translation?
It stops your body from wasting NAD+, so you actually get the full benefit from your injections.
And the science is rock solid.
A 2022 study published in Diabetes, Obesity, and Metabolism found that inhibiting NNMT in obese mice increased energy expenditure by 10%, reduced fat mass, and improved glucose metabolism—without changing diet or exercise.
Other studies have shown that blocking NNMT improves muscle strength, reduces neuroinflammation, and enhances mitochondrial function.
In short, with 5-Amino:
✅ More NAD+ stays available for energy, DNA repair, and cellular function.
✅ Metabolism speeds up, leading to easier fat loss.
✅ Brain function and muscle recovery improve significantly.
Sounds good, right?
But here’s the catch—not all 5-Amino-1MQ is created equal.
Injectable 5-Amino-1MQ vs. Oral Capsules: Which is Better?
If you’re serious about getting the most out of this stack, you will want to try injectable 5-Amino-1MQ.
Here’s why:
Injectable 5-Amino-1MQ (500mcg-1mg per day) has nearly 100% bioavailability. This means it goes straight into your bloodstream and starts inhibiting NNMT immediately.
Oral 5-Amino-1MQ (50-150mg per day) works, but it’s less effective because it has to pass through the liver first, where some of it is lost.
If you’re using oral capsules, you’ll need a much higher dose (50-150mg per day) compared to injectable doses (500mcg-1mg per day) to get similar results.
For maximum effect? Go injectable (You can find it at Amino Asylum for 20% off using code HUNTER20).
The Perfect NAD+ + 5-Amino-1MQ Protocol
If you’re ready to stop wasting your NAD+ injections and actually feel the benefits, here’s how to do it:
NAD+ Injection Protocol
100mg IM injection, 2-3x per week
(Most people feel best at 200-300mg per week)
5-Amino-1MQ Injection Protocol
500mcg-1mg per day (Injectable)
OR
50-150mg per day (Capsules)
With this optimized protocol, you’ll finally start to feel:
✔️ More energy and mental clarity
✔️ Faster muscle recovery and performance
✔️ Easier fat loss and better metabolic control
✔️ Stronger anti-aging effects at the cellular level
Final Thoughts
NAD+ therapy alone can be hit or miss—some people feel incredible, while others barely notice a difference.
The reason? NNMT may be sabotaging your results.
By inhibiting NNMT with 5-Amino-1MQ, you allow your body to fully use NAD+, leading to:
✅ Better energy production
✅ Improved metabolic function
✅ Faster recovery & muscle repair
✅ Sharper cognition & focus
This is one of the most powerful longevity stacks you can use.
If you’ve struggled with NAD+ injections not working, adding 5-Amino-1MQ could be the key to finally seeing results.
Best,
Hunter Williams
Epitalon
SS-31
MOTS-c
Further Reading
1. Roles of Nicotinamide N-Methyltransferase in Obesity and Type 2 Diabetes
2. Nicotinamide N-Methyltransferase (NNMT): A New Hope for Treating Metabolic Disorders
3. Nicotinamide N-Methyltransferase Inhibition Mitigates Obesity
4. Nicotinamide N-Methyltransferase Inhibition Mimics and Boosts Exercise-Mediated Improvements in Muscle Function in Aged Mice
5. Identification of Nicotinamide N-Methyltransferase as a Promising Therapeutic Target for Sarcopenia